James B. Ackman

MCD Biology
1156 High Street
Santa Cruz, CA 95064
phone: 831.502.0949
jackman@ucsc.edu

Education and Positions

Assistant Professor, University of California Santa Cruz, Santa Cruz, CA, Jan, 2015 – present

Associate Research Scientist, Yale University School of Medicine, New Haven, CT, Sep, 2012 – Dec, 2014

Postdoctoral Fellow, Yale University School of Medicine, New Haven, CT, May, 2008 – Aug, 2012
Advisor: Michael C. Crair

Postdoctoral Fellow, Mediterranean Institute of Neurobiology, Marseille, France, Sep, 2006 – Apr, 2008
Advisors: Alfonso Represa, Rosa Cossart, and Yesekiel Ben-Ari

Ph.D. Physiology and Neurobiology, University of Connecticut, Storrs, CT, Jun, 2006
Advisor: Joseph J. LoTurco

B.S. Physiology and Neurobiology, University of Connecticut, Storrs, CT, Dec, 1999
Minor in Molecular and Cell Biology

Publications

Rash BG, Ackman JB, and Rakic P. Bidirectional radial Ca(2+) activity regulates neurogenesis and migration during early cortical column formation, Sci Adv. 2016 2(2), e1501733

Ackman JB, Zeng H, Crair MC. Structured dynamics of neural activity across developing neocortex. bioRxiv 2014 doi: 10.1101/123456

Burbridge TJ, Xu HP, Ackman JB, Ge X, Zhang Y, Ye MJ, Zhou ZJ, Xu J, Contractor A, Crair MC. Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors. Neuron. 2014 Nov 20;84(5):1049-1064. doi: 10.1016/j.neuron.2014.10.051.

Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Curr Opin Neurobiol. 2014 Feb;24C:166-175.

Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system. Nature 2012 Oct 11;490, 219–225.

Zhang J, Ackman JB, Xu HP, Crair MC. Visual map development depends on the temporal pattern of binocular activity in mice. Nat Neurosci. 2011 Nov 18;15(2):298-307.

Zhang J*, Ackman JB*, Dhande OS, Crair MC. Visualization and manipulation of neural activity in the developing vertebrate nervous system. Front Mol Neurosci. 2011 Nov 18;4:43. *Equal contribution.

Ackman JB, Aniksztein L, Crépel V, Becq H, Pellegrino C, Cardoso C, Ben-Ari Y, Represa A. Abnormal Network Activity in a Targeted Genetic Model of Human Double Cortex. J Neurosci. 2009 Jan 14;29(2):313-27.

Pignatelli A, Ackman JB, Vigetti D, Beltrami AP, Zucchini S, Belluzzi O. A potential reservoir of immature dopaminergic replacement neurons in the adult mammalian olfactory bulb. Pflugers Archiv. 2009; 457(4):899-915.

Allène C, Cattani A, Ackman JB, Bonifazi P, Aniksztejn L, Ben-Ari Y, Cossart R. Sequential generation of two distinct synapse-driven network patterns in developing neocortex. J Neurosci. 2008 Nov 26;28(48):12851-63.

Bai J, Ramos RL, Paramasivam M, Siddiqi F, Ackman JB, LoTurco JJ. The role of DCX and LIS1 in migration through the lateral cortical stream of developing forebrain. Dev Neurosci. 2008; 30:144-56.

Ackman JB, Ramos RL, Sarkisian MR, LoTurco JJ. Citron kinase is required for postnatal neurogenesis in the hippocampus. Dev Neurosci. 2007; 29(1-2):113-23.

Ackman JB, Siddiqi F, Walikonis RW, LoTurco JJ. Fusion of microglia with pyramidal neurons after retroviral infection. J Neurosci. 2006 Nov 1;26(44):11413-22. 'Recommended' on Faculty of 1000

Ackman JB, LoTurco JJ. The potential of endogenous neuronal replacement in developing cerebral cortex following hypoxic injury. Exp Neurol. 2006 May;199(1):5-9.

Pignatelli A, Benedusi M, Ackman J, Loturco JJ, Belluzzi O. Functional Properties of Adult-born Juxtaglomerular Cells in the Mammalian Olfactory Bulb. Chem Senses. 2005 Jan;30 Suppl 1:i119-i120.

Bai J, Ramos RL*, Ackman JB*, Thomas AM, Lee RV, LoTurco JJ. RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat Neurosci. 2003 Dec; 6(12):1277-83. 'Recommended' on Faculty of 1000. *Equal contribution.

Belluzzi O, Benedusi M, Ackman J, LoTurco JJ. Electrophysiological differentiation of new neurons in the olfactory bulb. J Neurosci. 2003 Nov 12; 23(32):10411-8.

Invited Talks

UC Bioengineering Symposium, 'Technology and the Nervous System', Santa Cruz, CA. Mesoscale transcranial imaging of brain waves across the cerebral hemispheres, Jun 24, 2015

Yale University, 'Club Neurobiology', New Haven, CT. A Small World After All:  Mesoscale Functional Organization Across Developing Neocortex, Dec 2, 2014

University of California Santa Cruz, Santa Cruz, CA. Visualizing structured activity throughout the developing brain, Feb 10, 2014

Duke University, Durham, NC. Visualizing structured activity throughout the developing brain, Jan 30, 2014

Boston University, Boston, MA. Visualizing structured activity throughout the developing brain, Jan 21, 2014

Vollum Institute, Portland, OR. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Mar 4, 2013

University of Louisville, Louisville, KY. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Feb 25, 2013

University of California San Francisco, San Francisco, CA. Visualizing circuit structure and function throughout the developing brain, Feb 14, 2013

University of Oregon, Eugene, OR. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Feb 7, 2013

The Johns Hopkins University School of Medicine, Baltimore, MD. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Feb 4, 2013

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. Visualizing circuit structure and function throughout the developing brain, Jan 23, 2013

UT Southwestern Medical Center, Dallas, Texas. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Jan 8, 2013

Japan Neuroscience Society, Nagoya, Japan. Retinal waves coordinate patterned activity throughout the developing visual system in vivo, Sep 20, 2012

Fudan University, Shanghai, China. Retinal waves coordinate patterned activity throughout the developing visual system in vivo, Sep 17, 2012

Yale University, 'NeuroDay', New Haven, CT. The ebb and flow of brain development: Spontaneous waves propagate throughout the visual system in vivo, Jun 14, 2012

CSHL, 'Neuronal Circuits', Cold Spring Harbor, NY. Retinal waves coordinate patterned activity throughout the developing visual system in vivo, Mar 29, 2012

Amherst College, Amherst, MA. Emergent network activity and the development visual circuits, Mar 5, 2012

Harvard Medical School, Boston, MA. Development of spontaneous activities in malformed cortical networks. Jan 30, 2008

Brandeis University, Waltham, MA. Neuronal-glial interactions and spontaneous network activities during cortical development, Jan, 11, 2008

Yale University, New Haven, CT. Neuronal-glial interactions and spontaneous network activities during cortical development, Jan 3, 2008

Institut de Neurobiologie de la Méditerranée, Marseille, France. Neuronal-glial fusion in the postnatal neocortex: implications for cortical development and regeneration, Feb 27, 2006

Neuroscience Fellowship Talks, Storrs, CT. Neuronal-glial fusion in postnatal neocortex: implications for cortical development and regeneration, May 11, 2005

Abstracts

Gribizis A, Ackman JB, Crair MC. Glutamatergic (stage III) retinal waves and their role in visual development in vivo. Soc Neurosci Abstr, 2015

Rash BG, Ackman JB, Rakic P. Non-synaptic communication during early cortical column formation revealed by genetically encoded Ca2+ indicators. Soc Neurosci Abstr, 2015

Ackman JB, Zeng H, Crair MC. Functional mapping of developing neocortical networks. Soc Neurosci Abstr, 2014

Rash BG, Ackman JB, Rakic P. A growth factor-dependent Ca2+ signaling network during stem cell proliferation and neuronal migration in the developing neocortex. Soc Neurosci Abstr, 2014

Ackman JB, Crair MC. Structured population activity across developing isocortex. SfN Satellite Meeting: The Networked Brain, Nov 2013

Rash BG, Ackman JB, Rakic P. Neuronal migration and radial glial cell proliferation are regulated by calcium transient activity propagated through radial fibers during corticogenesis. Soc Neurosci Abstr, 2013

Ackman JB, Burbridge TJ, Crair MC. Spontaneous retinal waves propagate throughout the developing visual system in vivo. Soc Neurosci Abstr, Oct 2012

Burbridge TJ, Xu HP, Ackman JB, Crair MC. In vivo examination of retinal waves and visual map development in β2 nicotinic acetylcholine receptor whole animal and conditional deletion knockout mice. Soc Neurosci Abstr, Oct 2012

Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system in vivo. Japan Neuroscience Society, Nagoya, Japan, Sep 2012

Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system in vivo. CSHL, 'Neuronal Circuits', Mar 2012

Ackman JB, Zhang J, Crair MC. Temporal pattern prediction in the developing superior colliculus before eye opening. Soc Neurosci Abstr, 2010

Represa A, Lapray D, Becq H, Kindler J, Jorquera I, Crepel V, Aniksztejn L, Ackman J, Cardoso C, Luhman H. Increased cortical network excitability and epilepsy in an animal model of subcortical band heterotopia after in utero RNA knockdown of DCX. Soc Neurosci Abstr, 2009

Pignatelli A, Ackman J, Beltrami AP, Zucchini S, Gambardella C, Martins DC, Belluzzi O. Properties and maturation of adult-generated dopaminergic neurons in the mammalian olfactory bulb. Soc Neurosci Abstr, 2009

Allene C, Cattani A, Ackman JB, Bonifazi P, Aniksztejn L, Ben-Ari Y, Cossart R. Synaptic and extrasynaptic basis for the generation of early network oscillations in the developing cortex. Amino Acids, 2009 Jul; 37:27-37.

Allène C, Ackman JB, Bonifazi P, Cattani A, Aniksztejn L, Ben-Ari Y, Cossart R. Sequential generation of two distinct synapse-driven network patterns in developing neocortex. Soc Neurosci Abstr, 2008

Ackman JB, Becq H, Pelligrino C, Cardoso C, Ben-Ari Y, Represa A. Development of spontaneous activity patterns in dysplastic cortical networks. Soc Neurosci Abstr, 2007

Ackman JB, Becq H, Pelligrino C, Cardoso C, Ben-Ari Y, Represa A. Development of spontaneous activity patterns in dysplastic cortical networks. Gordon Research Conference, ‘Neural Circuits and Plasticity’, 2007

Siddiqi F, Bai J, Ramos RL, Ackman JB, LoTurco JJ. Doublecortin overexpression induces neuronal differentiation at the expense of astrocytes. Soc Neurosci Abstr, 2006

Ackman JB, Siddiqi F, Zwang ML, Walikonis RW, LoTurco JJ. A source of mistaken neurogenesis: microglial-neuronal fusion in postnatal cerebral cortex. Soc Neurosci Abstr, 2005

Ackman JB, LoTurco JJ. Retroviral evidence for generation of neurons in postnatal neocortex. Soc Neurosci Abstr, 2004

Pathak H, Ackman J, LoTurco J, Coulter DA. Abnormal Inhibitory Innervation of Adult Born Neurons in the Dentate Gyrus Following Status Epilepticus. Soc Neurosci Abstr, 2004

Belluzzi O, Benedusi M, Ackman J, LoTurco JJ. Functional aspects of neurogenesis in the adult olfactory bulb. AChemS Abstr, 2003

Ackman JB, LoTurco JJ. Postnatal generation of neocortical pyramidal neurons in the flathead mutant rat. Soc Neurosci Abstr, 2003

Bai J, Ramos RL, Ackman JB, Thomas AM, LoTurco JJ. Doublecortin is required for radial migration in neocortex. Soc Neurosci Abstr, 2003

Ramos R, Ackman JB, LoTurco JJ, Chrobak JJ. Physiology and morphology of nucleus renunions neurons in vitro: Implications for the hippocampal memory system. Soc Neurosci Abstr, 2003

Pathak H, Kelly ME, Ackman J, LoTurco J, Lowenstein DH, Coulter DA. Synaptic integration of newborn neurons in adult dentate gyrus following status epilepticus. Soc Neurosci Abstr, 2003

Ackman JB, Benedusi M, Belluzzi O, LoTurco JJ. Fate and function of newly generated interneurons in the adult rodent olfactory bulb. Soc Neurosci Abstr, 2002

Kelly ME, Pathak H, Ackman J, LoTurco J, Lowenstein DH, Coulter DA. Morphological characterization of newborn dentate granule cells in epileptic and control rats using a retroviral vector expressing green fluorescent protein. American Epilepsy Society Abstr, 2002

Ackman JB, LoTurco JJ. Barrel formation and deformation in the neocortex of the flathead mutant. Soc Neurosci Abstr, 2000

Professional affiliations

Society for Neuroscience