James B. Ackman

jackman@ucsc.edu

Education and Positions

Assistant Professor, University of California Santa Cruz, Santa Cruz, CA, Jan, 2015 – present

Associate Research Scientist, Yale University School of Medicine, New Haven, CT, Sep, 2012 – Dec, 2014

Postdoctoral Fellow, Yale University School of Medicine, New Haven, CT, May, 2008 – Aug, 2012

Postdoctoral Fellow, Mediterranean Institute of Neurobiology, Marseille, France, Sep, 2006 – Apr, 2008

Ph.D. Physiology and Neurobiology, University of Connecticut, Storrs, CT, Jun, 2006

B.S. Physiology and Neurobiology, University of Connecticut, Storrs, CT, Dec, 1999
Minor in Molecular and Cell Biology

Publications

  1. Rash BG, Ackman JB, and Rakic P. Bidirectional radial Ca(2+) activity regulates neurogenesis and migration during early cortical column formation. Sci Adv (2016). 2(2):e1501733. doi:10.1126/sciadv.1501733 PMID:26933693

  2. Burbridge TJ, Xu H, Ackman JB, Ge X, Zhang Y, Ye M, Zhou ZJ, Xu J, Contractor A, and Crair MC. Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors. Neuron (2014). 84(5):1049-64. doi:10.1016/j.neuron.2014.10.051 PMID:25466916

  3. Ackman JB and Crair MC. Role of emergent neural activity in visual map development. Curr Opin Neurobiol (2014). 24C:166-175. doi:10.1016/j.conb.2013.11.011 PMID:24492092

  4. Ackman JB, Zeng H, and Crair MC. Structured dynamics of neural activity across developing neocortex. bioRxiv (2014). doi:10.1101/012237

  5. Ackman JB, Burbridge TJ, and Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system. Nature (2012). 490(7419):219-25. doi:10.1038/nature11529 PMID:23060192

  6. Zhang J, Ackman JB, Xu H, and Crair MC. Visual map development depends on the temporal pattern of binocular activity in mice. Nat Neurosci (2011). 15(2):298-307. doi:10.1038/nn.3007 PMID:22179110

  7. Zhang J^1^, Ackman JB^1^, Dhande OS, and Crair MC. Visualization and manipulation of neural activity in the developing vertebrate nervous system. Front Mol Neurosci (2011). 4:43. doi:10.3389/fnmol.2011.00043 PMID:22121343 ^1^Equal contribution.

  8. Pignatelli A, Ackman JB, Vigetti D, Beltrami AP, Zucchini S, and Belluzzi O. A potential reservoir of immature dopaminergic replacement neurons in the adult mammalian olfactory bulb. Pflugers Arch (2009). 457(4):899-915. doi:10.1007/s00424-008-0535-0 PMID:19011893

  9. Ackman JB^1^, Aniksztejn L^1^, Crépel V, Becq H, Pellegrino C, Cardoso C, Ben-Ari Y, and Represa A. Abnormal network activity in a targeted genetic model of human double cortex. J Neurosci (2009). 29(2):313-27. doi:10.1523/JNEUROSCI.4093-08.2009 PMID:19144832 ^1^Equal contribution.

  10. Allène C, Cattani A, Ackman JB, Bonifazi P, Aniksztejn L, Ben-Ari Y, and Cossart R. Sequential generation of two distinct synapse-driven network patterns in developing neocortex. J Neurosci (2008). 28(48):12851-63. doi:10.1523/JNEUROSCI.3733-08.2008 PMID:19036979

  11. Bai J, Ramos RL, Paramasivam M, Siddiqi F, Ackman JB, and LoTurco JJ. The role of DCX and LIS1 in migration through the lateral cortical stream of developing forebrain. Dev Neurosci (2008). 30(1-3):144-56. doi:10.1159/000109859 PMID:18075262

  12. Ackman JB, Ramos RL, Sarkisian MR, and Loturco JJ. Citron kinase is required for postnatal neurogenesis in the hippocampus. Dev Neurosci (2007). 29(1-2):113-23. doi:10.1159/000096216 PMID:17148954

  13. Ackman JB, Siddiqi F, Walikonis RS, and LoTurco JJ. Fusion of microglia with pyramidal neurons after retroviral infection. J Neurosci (2006). 26(44):11413-22. doi:10.1523/JNEUROSCI.3340-06.2006 PMID:17079670 ‘Recommended’ on Faculty of 1000.

  14. Ackman JB and LoTurco JJ. The potential of endogenous neuronal replacement in developing cerebral cortex following hypoxic injury. Exp Neurol (2006). 199(1):5-9. doi:10.1016/j.expneurol.2006.03.007 PMID:16630614

  15. Pignatelli A, Benedusi M, Ackman J, Loturco JJ, and Belluzzi O. Functional properties of adult-born juxtaglomerular cells in the mammalian olfactory bulb. Chem Senses (2005). 30 Suppl 1:i119-20. doi:10.1093/chemse/bjh143 PMID:15738068

  16. Bai J, Ramos RL^2^, Ackman JB^2^, Thomas AM, Lee RV, and LoTurco JJ. RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat Neurosci (2003). 6(12):1277-83. doi:10.1038/nn1153 PMID:14625554 ^2^Equal contribution. ‘Recommended’ on Faculty of 1000.

  17. Belluzzi O, Benedusi M, Ackman J, and LoTurco JJ. Electrophysiological differentiation of new neurons in the olfactory bulb. J Neurosci (2003). 23(32):10411-8. PMID:14614100

Invited Talks

Bioengineering Symposium, ‘Technology and the Nervous System’, Santa Cruz, CA. Mesoscale transcranial imaging of brain waves across the cerebral hemispheres, Jun 24, 2015

Yale University, ‘Club Neurobiology’, New Haven, CT. A Small World After All:  Mesoscale Functional Organization Across Developing Neocortex, Dec 2, 2014

University of California Santa Cruz, Santa Cruz, CA. Visualizing structured activity throughout the developing brain, Feb 10, 2014

Duke University, Durham, NC. Visualizing structured activity throughout the developing brain, Jan 30, 2014

Boston University, Boston, MA. Visualizing structured activity throughout the developing brain, Jan 21, 2014

Vollum Institute, Portland, OR. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Mar 4, 2013

University of Louisville, Louisville, KY. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Feb 25, 2013

University of California San Francisco, San Francisco, CA. Visualizing circuit structure and function throughout the developing brain, Feb 14, 2013

University of Oregon, Eugene, OR. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Feb 7, 2013

The Johns Hopkins University School of Medicine, Baltimore, MD. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Feb 4, 2013

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. Visualizing circuit structure and function throughout the developing brain, Jan 23, 2013

UT Southwestern Medical Center, Dallas, Texas. Visualizing the visual system: Patterned activity and the emergence of neural circuits, Jan 8, 2013

Japan Neuroscience Society, Nagoya, Japan. Retinal waves coordinate patterned activity throughout the developing visual system in vivo, Sep 20, 2012

Fudan University, Shanghai, China. Retinal waves coordinate patterned activity throughout the developing visual system in vivo, Sep 17, 2012

Yale University, ‘NeuroDay’, New Haven, CT. The ebb and flow of brain development: Spontaneous waves propagate throughout the visual system in vivo, Jun 14, 2012

CSHL, ‘Neuronal Circuits’, Cold Spring Harbor, NY. Retinal waves coordinate patterned activity throughout the developing visual system in vivo, Mar 29, 2012

Amherst College, Amherst, MA. Emergent network activity and the development visual circuits, Mar 5, 2012

Harvard Medical School, Boston, MA. Development of spontaneous activities in malformed cortical networks. Jan 30, 2008

Brandeis University, Waltham, MA. Neuronal-glial interactions and spontaneous network activities during cortical development, Jan, 11, 2008

Yale University, New Haven, CT. Neuronal-glial interactions and spontaneous network activities during cortical development, Jan 3, 2008

Institut de Neurobiologie de la Méditerranée, Marseille, France. Neuronal-glial fusion in the postnatal neocortex: implications for cortical development and regeneration, Feb 27, 2006

Presentations

  1. Gribizis A, Ge X, Ackman JB, Lee D., Crair MC. Late stage spontaneous waves and their role in downstream visual areas in vivo. Soc Neurosci Abstr, 2017

  2. Mullen BR, Mayo JD, Hill SL, Fong A, Ackman JB. A modular system for transcranial optical imaging in awake/behaving mice. Soc Neurosci Abstr, 2016

  3. Gribizis A, Ackman JB, Crair MC. Glutamatergic (stage III) retinal waves and their role in visual development in vivo. Soc Neurosci Abstr, 2015

  4. Rash BG, Ackman JB, Rakic P. Non-synaptic communication during early cortical column formation revealed by genetically encoded Ca2+ indicators. Soc Neurosci Abstr, 2015

  5. Ackman JB, Zeng H, Crair MC. Functional mapping of developing neocortical networks. Soc Neurosci Abstr, 2014

  6. Rash BG, Ackman JB, Rakic P. A growth factor-dependent Ca2+ signaling network during stem cell proliferation and neuronal migration in the developing neocortex. Soc Neurosci Abstr, 2014

  7. Ackman JB, Crair MC. Structured population activity across developing isocortex. SfN Satellite Meeting: The Networked Brain, Nov 2013

  8. Rash BG, Ackman JB, Rakic P. Neuronal migration and radial glial cell proliferation are regulated by calcium transient activity propagated through radial fibers during corticogenesis. Soc Neurosci Abstr, 2013

  9. Ackman JB, Burbridge TJ, Crair MC. Spontaneous retinal waves propagate throughout the developing visual system in vivo. Soc Neurosci Abstr, Oct 2012

  10. Burbridge TJ, Xu HP, Ackman JB, Crair MC. In vivo examination of retinal waves and visual map development in β2 nicotinic acetylcholine receptor whole animal and conditional deletion knockout mice. Soc Neurosci Abstr, Oct 2012

  11. Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system in vivo. Japan Neuroscience Society, Nagoya, Japan, Sep 2012

  12. Ackman JB, Burbridge TJ, Crair MC. Retinal waves coordinate patterned activity throughout the developing visual system in vivo. CSHL, ‘Neuronal Circuits’, Mar 2012

  13. Ackman JB, Zhang J, Crair MC. Temporal pattern prediction in the developing superior colliculus before eye opening. Soc Neurosci Abstr, 2010

  14. Represa A, Lapray D, Becq H, Kindler J, Jorquera I, Crepel V, Aniksztejn L, Ackman J, Cardoso C, Luhman H. Increased cortical network excitability and epilepsy in an animal model of subcortical band heterotopia after in utero RNA knockdown of DCX. Soc Neurosci Abstr, 2009

  15. Pignatelli A, Ackman J, Beltrami AP, Zucchini S, Gambardella C, Martins DC, Belluzzi O. Properties and maturation of adult-generated dopaminergic neurons in the mammalian olfactory bulb. Soc Neurosci Abstr, 2009

  16. Allene C, Cattani A, Ackman JB, Bonifazi P, Aniksztejn L, Ben-Ari Y, Cossart R. Synaptic and extrasynaptic basis for the generation of early network oscillations in the developing cortex. Amino Acids, 2009 Jul; 37:27-37.

  17. Allène C, Ackman JB, Bonifazi P, Cattani A, Aniksztejn L, Ben-Ari Y, Cossart R. Sequential generation of two distinct synapse-driven network patterns in developing neocortex. Soc Neurosci Abstr, 2008

  18. Ackman JB, Becq H, Pelligrino C, Cardoso C, Ben-Ari Y, Represa A. Development of spontaneous activity patterns in dysplastic cortical networks. Soc Neurosci Abstr, 2007

  19. Ackman JB, Becq H, Pelligrino C, Cardoso C, Ben-Ari Y, Represa A. Development of spontaneous activity patterns in dysplastic cortical networks. Gordon Research Conference, ‘Neural Circuits and Plasticity’, 2007

  20. Siddiqi F, Bai J, Ramos RL, Ackman JB, LoTurco JJ. Doublecortin overexpression induces neuronal differentiation at the expense of astrocytes. Soc Neurosci Abstr, 2006

  21. Ackman JB, Siddiqi F, Zwang ML, Walikonis RW, LoTurco JJ. A source of mistaken neurogenesis: microglial-neuronal fusion in postnatal cerebral cortex. Soc Neurosci Abstr, 2005

  22. Ackman JB, LoTurco JJ. Retroviral evidence for generation of neurons in postnatal neocortex. Soc Neurosci Abstr, 2004

  23. Pathak H, Ackman J, LoTurco J, Coulter DA. Abnormal Inhibitory Innervation of Adult Born Neurons in the Dentate Gyrus Following Status Epilepticus. Soc Neurosci Abstr, 2004

  24. Belluzzi O, Benedusi M, Ackman J, LoTurco JJ. Functional aspects of neurogenesis in the adult olfactory bulb. AChemS Abstr, 2003

  25. Ackman JB, LoTurco JJ. Postnatal generation of neocortical pyramidal neurons in the flathead mutant rat. Soc Neurosci Abstr, 2003

  26. Bai J, Ramos RL, Ackman JB, Thomas AM, LoTurco JJ. Doublecortin is required for radial migration in neocortex. Soc Neurosci Abstr, 2003

  27. Ramos R, Ackman JB, LoTurco JJ, Chrobak JJ. Physiology and morphology of nucleus renunions neurons in vitro: Implications for the hippocampal memory system. Soc Neurosci Abstr, 2003

  28. Pathak H, Kelly ME, Ackman J, LoTurco J, Lowenstein DH, Coulter DA. Synaptic integration of newborn neurons in adult dentate gyrus following status epilepticus. Soc Neurosci Abstr, 2003

  29. Ackman JB, Benedusi M, Belluzzi O, LoTurco JJ. Fate and function of newly generated interneurons in the adult rodent olfactory bulb. Soc Neurosci Abstr, 2002

  30. Kelly ME, Pathak H, Ackman J, LoTurco J, Lowenstein DH, Coulter DA. Morphological characterization of newborn dentate granule cells in epileptic and control rats using a retroviral vector expressing green fluorescent protein. American Epilepsy Society Abstr, 2002

  31. Ackman JB, LoTurco JJ. Barrel formation and deformation in the neocortex of the flathead mutant. Soc Neurosci Abstr, 2000

Grants and funding

Hellman Fellowship, Role: PI, 2017 – 2018

Startup funds from University of California, Santa Cruz, Physical and Biological Sciences, Role: PI, 2015 – 2018

Honors and awards

Selected presentation, ‘Structured population activity across developing isocortex’, SfN Satellite Meeting: The Networked Brain, Nov 2013
SfN Travel Award to Japan Neuroscience Society Meeting in Nagoya, Japan, Sep 2012
NIH National Research Service Award T32, 2008 – 2010
INSERM Postdoctoral Fellowship for Foreign Researchers, Oct 2006 – Sep 2007
Doctoral Dissertation Fellowship, University of Connecticut, 2006
Neuroscience Fellow, University of Connecticut, 2004 – 2005
Cover image, Nature Neuroscience Vol. 6 No. 12, 2003

Teaching

Instructor, Introduction to Neuroscience/BIOL 125 (enrollment 114), UC Santa Cruz, Fall 2016

Instructor, Introduction to Neuroscience/BIOL 125 (enrollment 43), UC Santa Cruz, Winter 2016

Manager, Vision Core imaging facility in Department of Neurobiology, Yale University. Trained users in principles and practice of using laser-scanning two-photon microscopy, 2008 – 2012

Manager, Confocal microscope facility in Department of Physiology and Neurobiology, University of Connecticut. Trained users in principles and practice of using laser-scanning confocal microscopy, 2002 – 2006

Mentorship, ‘Brain Power’, UConn Mentor Connection for high school students in neuroscience research, Storrs, CT Summer 2003

Teaching Assistant, Biology of the Brain/PNB 251, University of Connecticut, Spring 2002

Teaching Assistant, Investigations in Neurobiology Laboratory/PNB 263W, University of Connecticut, Fall 2001

Teaching Assistant, Investigations in Neurobiology Laboratory/PNB 263W, University of Connecticut, Fall 2000

Teaching Assistant, Human Anatomy and Physiology Laboratory/PNB 265, University of Connecticut, Spring 2000

Mentoring and student advising

Doctoral students

Brian Mullen, 2015 – present
Sydney Weiser, 2016 – present
Jason Mayo, 2016 – present

Masters students

Jacqueline Lamb, 2017 – present

Undergraduate students

Jessica Jones, 2017 – present, STEM program
Antonia Fuller, 2017 – present
Claire Bachmeier, 2017 – present
Anastasia Rejniak, 2017 – present
Shona Allen, 2017 junior specialist at UCSF
Sophia Jochnowitz, 2017 – present
Sarah Hill, 2016 – 2017 masters program at Univ British Columbia
Robert Stover, 2016 – 2017 lab tech at Two Pore Guys
Jacqueline Lamb, 2016 – 2017 masters program at UC Santa Cruz
Abraham Rodriguez, 2016 – 2017, STEM program
Sara Stith, 2016
Luis Aguilar, 2016
Condy Kan, 2016 research assistant at UCLA
Tyler Berkness, 2015 – present
Ashmitha Rajendran, 2015 – present
Dolly Kapoor, 2015 – 2016
Sumanth Gollapudi, 2015 – 2016 graduate school
Lana Frankle, 2015 – 2016 graduate school at Kent State
Chad Santo Tomas, 2015 – 2016, STEM program research assistant at UC Santa Cruz
Anthony Fong, 2015 – 2016 research assistant at UCSF
Chelsea Messinger, 2013 – 2013 MD/PhD program at Harvard Univ

Graduate thesis committees

Anthony Gilmore, 2016 – present
James Perna, 2016 – present
Michelle Tjia, 2015 – present

Graduate candidacy examinations

Kendy Hoang, 2017
David Tastad, 2017
James Perna, 2016
Michelle Tjia, 2015

Service to the field

Reviewer, Journal of Neuroscience, Jan 2017
Co-Author, pyWholeBrain brain wave imaging software, 2016 – 2017
Reviewer, Journal of Neuroscience, Jul 2016
Reviewer, Journal of Neuroscience, May 2016
Reviewer, Frontiers in Neural Circuits, Jun 2016
Author, dFoF ImageJ calcium imaging software, 2012, 2014, 2016
Author, wholeBrainDX widefield functional imaging software, 2012 – 2016
Author, CalciumDX calcium imaging software, 2011 – 2012, 2014
Reviewer, Frontiers in Integrative Neuroscience, Dec 2012

Service to the university

Mentor, STEM Diversity Program, 2017 – present
Co-presenter, MCD Retreat talk presentation, Sep 2017
Co-presenter, MCD Retreat poster presentation, Sep 2017
Co-presenter, PBSE Retreat poster presentation, Sep 2017
Author, ‘lambdaBuildBot’ AWS Lambda app build and deploy bot, 2017
Author, ‘woola’ markdown to html/pdf content rendering, build, and server app, 2017
Particpant, Neurosociety exhibit, Palo Alto, CA, Feb 2017
Member, Graduate admissions committee, 2016 – 2017
Mentor, STEM Diversity Program, 2016 – 2017
Author, BIOL 125/Introduction to Neuroscience instructional web app, see syllabus, Sep 2016 – Dec 2016
Co-presenter, PBSE Retreat poster presentation, Sep 2016
Presenter, PBSE Graduate research orientation faculty research overview, Sep 2016
Member, Graduate admissions committee, 2015 – 2016
Presenter, BME 280B Seminar, Oct 2015
Presenter, PBSE Graduate research orientation faculty research overview, Sep 2015
Presenter, PBSE Retreat Track Spotlight talk, Sep 2015
Author and Instructor, PBSE Graduate research orientation experiments, Neuroinformatics/Brain connectivity mini-course, Sep 2015
Mentor, STEM Diversity Program, 2015 – 2016
Chair, 16th Annual UC Systemwide Bioengineering Symposium, session ‘Technology and the Nervous System’, Santa Cruz, CA. Jun 24, 2015

Service to the community

Guest speaker, Pacific Collegiate School, ‘Lunch with a scientist’, Santa Cruz, CA, Apr 2017
Volunteer, Beach Cleanup, Santa Cruz, CA 2015 – present
Volunteer, Coastal Community Preschool, Santa Cruz, CA 2016 – present
Contributing author, Wikipedia, 2014, 2016, 2017
Mentor, ACCESS academic bridge program, Santa Cruz, CA Jun – Aug 2016
Contributing author, BibDeskToWord bibliography integration software, 2014, 2016
Guest speaker, Osher Lifelong Learners, UC Santa Cruz, Santa Cruz, CA, Oct 2015

Professional training

Introduction to Data Science, Coursera, University of Washington, May – Jul 2013
Scientific Leadership and Management, Yale University, Aug 2012
Neurobiology of Cortical Systems course with M. Crair, J. Mazer, D. McCormick, Yale University 2012
Neuroinformatics course with G. Shepherd, M. Hines, T. Carnavale Yale University Spring 2011
SfN short course, Networks of the Brain with O. Sporns, 2008

Professional affiliations

Society for Neuroscience